Instagram launched on the Android platform last month after the picture-sharing app gained more than 30 million users on Apple's iPhone. It was subsequently bought by Facebook in a $1bn (£62m) deal.
Schiller, who is heavily involved in iPhone marketing, later clarified his comments to another user by email, claiming he deleted his account because the Instagram community had grown too large.
He wrote: "One of the things I really liked about Instagram was that it was a small community of early adopters sharing their photographs. Now that it has grow [sic] much larger the signal to noise ratio is different.
"That isn’t necessarily good or bad, it’s just not what I originally had fun with."
He is one of a number of Instagram users to stop using the service in recent weeks, although most appear to be associated with Facebook's takeover, rather than Instagram's launch on Android.
Twitter co-founder Jack Dorsey also deleted his account following reports that Twitter wanted to buy Instagram before Facebook.
Instagram has been downloaded on Android more than 5 million times since it was released, and now has more than 40 million users in total.
